Valencia 4-1 Real Madrid: Carlos Soler scores a hat-trick of penalties to stun La Liga champions and pile the pressure back on Zinedine Zidane.
Karim Benzema put visitors Real ahead from long range before Soler equalised from a twice-taken penalty following an encroachment.
Reigning champions Real were looking to move one point behind Spanish top-flight leaders Real Sociedad before the international break.
But Zinedine Zidane‘s side remain four points off the summit after this heavy defeat, although they do have a game in hand.
To add to their problems, Benzema failed to finish the game after going off injured.
There was no sign of what was to follow when France forward put the visitors ahead with a scorching strike from outside the area.
Valencia levelled through a twice-taken penalty, which had been awarded after Lucas Vazquez handled.
Soler had his spot-kick saved by Thibaut Courtois and hit the post with the rebound. Team-mate Yunus Musah then poked the loose ball home, only for the goal to be ruled out after a video assistant referee (VAR) review showed him encroaching in the area.
A retake was ordered and Soler made it 1-1.
The hosts, who only had one attempt on target in the first half, took the lead before the breakthrough a bizarre own goal by Varane, who sent the ball over his head and over the line – the goal awarded several minutes later following another VAR review.
In an astonishing match, Valencia went on to score from two more penalties – 23-year-old Soler becoming only the third player in La Liga history to score three spot-kicks in a game.